AS1411
From Kidney Cancer Resource
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Overview
AS1411 is a cancer drug produced by Antisoma
Details
AS1411
AS1411 has shown activity against a wide range of solid and blood cancer cell lines in preclinical experiments and could therefore have potential against a variety of human cancers. Initial clinical development is focused on one blood cancer, AML (acute myeloid leukaemia) and one solid tumour, renal cancer (kidney cancer or renal cell carcinoma). A phase II clinical trial is ongoing in AML and a phase II trial is planned in renal cancer.
A previous phase I trial of AS1411 in 30 patients with various advanced cancers reported no serious adverse events related to treatment. Promising signs of anti-cancer activity were seen among patients in the trial with renal cancer (see below).
AS1411 is an aptamer. This is a type of drug based on a short piece of DNA or RNA. However, unlike some other drugs based on these chemicals, aptamers work as conventional drugs, binding to a protein target by virtue of a fit with its three-dimensional structure. The term aptamer is derived from the Greek ‘aptos’ (to fit).
AS1411 has a structure that allows it to bind specifically to a protein called nucleolin, which is found on the surface of many cancer cells. One bound, the AS1411 aptamer is taken into the cancer cell, where it causes death by apoptosis (programmed cell death).
Renal cancer
In the phase I trial of AS1411 there were 12 patients with advanced renal cancer. Promising signs of anti-tumour activity were seen in this group, including two objective responses with substantial tumour shrinkage. In addition to these clinical findings, renal cancer cell lines have shown high sensitivity to AS1411. We are planning to start a phase II trial in renal cancer in 2008.
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Articles
Earth Times (KC) 05-Sep-08
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