Genentech

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Overview

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Corporate Overview

Considered the founder of the biotechnology industry, Genentech has been delivering on the promise of biotechnology for more than 30 years, using human genetic information to discover, develop, commercialize and manufacture biotherapeutics that address significant unmet medical needs. Today, Genentech is among the world's leading biotech companies, with multiple products on the market for serious or life-threatening medical conditions and over 50 projects in the pipeline. The company is the leading provider of anti-tumor therapeutics in the United States. With its strength in all areas of the drug development process — from research and development to manufacturing and commercialization — Genentech continues to transform innovative science into breakthrough therapies for patients. For more general information about the company, visit our corporate overview section.

Details

PRODUCTS

Product Information

Delivering innovative medicines to patients with serious or life-threatening medical conditions is what Genentech is all about. Since its beginning in 1976, the company has focused its drug discovery efforts on therapies that would fill unmet needs. Today, Genentech manufactures and commercializes multiple protein-based biotherapeutics for serious or life-threatening medical conditions — giving Genentech one of the leading product portfolios in the biotech industry. 

Adverse events with any of Genentech's products can be reported to Genentech at (888) 835-2555.

BioOncology

Avastin® (bevacizumab)

Anti-VEGF antibody For use in combination with intravenous 5-fluorouracil-based chemotherapy for first- or second-line treatment of patients with metastatic carcinoma of the colon or rectum; in combination with carboplatin and paclitaxel for the first-line treatment of patients with unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer (NSCLC)

Herceptin® (Trastuzumab)

Anti-HER2 antibody For metastatic breast cancer in HER2 overexpressed tumors; as part of a treatment regimen containing doxorubicin, cyclophosphamide, and paclitaxel, for the adjuvant treatment of patients with HER2-positive, node-positive breast cancer

Rituxan® (Rituximab)

Anti-CD20 antibody For relapsed or refractory, low-grade or follicular, CD20-positive, B-cell non-Hodgkin's lymphoma (NHL); for the first-line treatment of diffuse large B-cell, CD20-positive, non-Hodgkin's lymphoma (DLBCL- a type of NHL) in combination with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) or other anthracycline-based chemotherapy regimens; for the first-line treatment of follicular, CD20-positive, B-cell non-Hodgkin's lymphoma in combination with CVP (cyclophosphamide, vincristine and prednisolone) chemotherapy; and for the treatment of low-grade, CD20-positive, B-cell non-Hodgkin's lymphoma in patients with stable disease or who achieve a partial or complete response following first-line treatment with CVP chemotherapy

Tarceva® (erlotinib)

Small molecule HER1/EGFR inhibitor For the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen; in combination with gemcitabine chemotherapy for the treatment of advanced pancreatic cancer in patients who have not received previous chemotherapy

For more information about Genentech BioOncology, please visit www.biooncology.com.

Immunology

Raptiva® (efalizumab)

Anti-CD11a antibody For chronic moderate-to-severe plaque psoriasis in adults age 18 or older

Rituxan® (Rituximab)

Anti-CD20 antibody For use in combination with methotrexate (MTX) for reducing signs and symptoms in adult patients with moderately- to severely-active rheumatoid arthritis (RA) who have had an inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies

Xolair® (Omalizumab) for Subcutaneous Use

Anti-IgE antibody For moderate-to-severe persistent asthma in adults and adolescents

Tissue Growth and Repair

Activase® (Alteplase)

A tissue-plasminogen activator For acute myocardial infarction, acute ischemic stroke and acute massive pulmonary embolism

Cathflo® Activase® (Alteplase)

Thrombolytic agent For the restoration of function to central venous access devices as assessed by the ability to withdraw blood

Lucentis® (ranibizumab injection) 

Antibody fragment For the treatment of neovascular (wet) age-related macular degeneration (AMD)

Nutropin® [somatropin (rDNA origin) for injection] 

Growth hormone For GHD in children and adults; growth failure associated with chronic renal insufficiency prior to kidney transplantation; short stature associated with Turner syndrome; long-term treatment of children with idiopathic (of unknown origin) short stature

Nutropin AQ® [somatropin (rDNA origin) injection] 

Liquid formulation growth hormone For GHD in children and adults; growth failure associated with chronic renal insufficiency prior to kidney transplantation; short stature associated with Turner syndrome; long-term treatment of children with idiopathic (of unknown origin) short stature

Nutropin AQ Pen® for use with Nutropin AQ Pen® Cartridge [somatropin (rDNA origin) injection] 

Liquid formulation growth hormone in a prefilled cartridge delivery device


Pulmozyme® (dornase alfa)

Inhalation Solution For management of cystic fibrosis (including patients under age 5)

TNKase® (Tenecteplase)

Single-bolus thrombolytic agent For the treatment of acute myocardial infarction


Articles

Medical Health Articles (PC) 16-Oct-07

Medical Health Articles (KC) 16-Oct-07


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