17-AAG
From Kidney Cancer Resource
Contents |
Overview
17-AAG is an antibiotic. 17-N-allylamino-17-demethoxygeldanamycin. A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics. Also called 17-N-allylamino-17-demethoxygeldanamycin.
As of June 2005, 17-N-allylamino-17-demethoxygeldanamycin is undergoing Phase 1 and Phase 2 clinical trials.
17-AAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. Hsp90 plays a key role in regulating the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. 17-AAG binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins that require this chaperone for conformational maturation
Articles
The Gazette (Montreal) (KC) 24-Feb-08
- Eye-cancer treatment shows promise
References
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