Cytoreductive
From Kidney Cancer Resource
Contents |
Overview
Cytoreductive therapy to reduce the number of cells in a lesion, usually a malignancy.
Definition:
Open Cytoreductive nephrectomy is the exact same operation as an open radical nephrectomy.
However, the open cytoreductive nephrectomy is done in the setting of kidney cancer that has extended outside of the kidney and its surrounding tissues.
The extent of the cancer may be limited to tissues in the area around the kidney known as the lymph nodes, or the kidney cancer may have more extensively spread to other organs such as the lung or liver.
OBJECTIVES:
Cytoreductive nephrectomy is commonly performed in patients with metastatic renal cell carcinoma before systemic interleukin-2 (IL-2) therapy.
Open nephrectomy is associated with prolonged recovery during which metastatic disease can progress.
Considering an open cytoreductive nephrectomy implied that, prior to the surgery, your doctor already knows that the cancer has spread outside the kidney to another organ and therefore removal of the kidney alone is not going to result in cure.
After the cytoreductive other systemic treatment strategies will be needed to increase the chance of cure and to extend life as much as possible.
Open cytoreductive nephrectomy was not performed in the past if the patient did not have symptoms such as pain or bleeding. However, it has been proven in two separate large clinical trials that open cytoreductive nephrectomy afford patients a slight improvement in survival and will extend life for a period of time that is usually in the range of three months to a year.
Articles
Uro Today (KC) 20-Mar-07
- Laparoscopic Cytoreductive Nephrectomy:: The M. D. Anderson Cancer Center Experience
Pub Meds (KC) Mar-99
- Laparoscopic cytoreductive nephrectomy as preparation for administration of systemic interleukin-2 in the treatment of metastatic renal cell carcinoma: a pilot study.
KC Institute (KC) 001
- Open Cytoreductive Nephrectomy
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