Kidney Cancer Drugs

From Kidney Cancer Resource

Contents 1 Overview 2 Drugs 2.1 Interferon Alpha 2.2 Interleukin-2 2.3 Sutent 2.4 Nexavar 2.5 Torisel 2.6 Avastin 2.7 Afinitor 2.8 Pazopanib 3 Drugs in Trial 3.1 Perifosine 3.2 AS1411 3.3 IMC-1121B 3.4 Perifosine 3.5 Flex-Hets 3.6 Rh-Apo2L 3.7 Trovax 3.8 BC-819 4 Drugs in the Research Phase 4.1 Axitinib 4.2 Light Activated Molecules 5 Drug Funding 6 Pain Killers 6.1 General Pain Killers 7 References 8 Disclaimer 9 E&OE - Errors & Omissions Excepted

Overview

A list the drugs that can be used in the treatment of Kidney Cancer, please click on each drug heading for a more detailed description

We also list some of the drugs currently in research and clinical trials.

Drugs

Interferon Alpha

Interleukin-2

• High Dose or Low dose Interleukin is also known by the trade/marketing name of Proleukin.
• The generic name for Interleukin & Proleukin is Aldesleukin

Sutent

• Sutent is the Trade/Marketing name for Sunitinib

Nexavar

• Nexavar is the Trade/Marketing name for Sorafenib

Torisel

• Torisel is the Trade/Marketing name for Temsirolimus

Avastin

• (licensed only in combination with Interferon)
• Avastin is the Trade/Marketing name for Bevacizumab

Afinitor

• Afinitor ( also known as RAD001) is the Trade/Marketing name for Everolimus

Pazopanib

Drugs in Trial

Perifosine

AS1411

IMC-1121B

In trial phase II as of August 2007. A total of 36 patients are expected to be enrolled.

Perifosine

In trial phase II as of March 2007, expected to end December 2007. Has shown some signs of working on Renal Cell Carcinoma

Flex-Hets

Rh-Apo2L

In Phase II and IIB trials as of October 2007

Trovax

• trial terminated due to adverse reactions ( patient deaths)

BC-819

Drugs in the Research Phase

Axitinib

Light Activated Molecules

Drug Funding

• For support & advice on how to apply for NHS funding for kidney cancer drugs please see www.kidneycancersupportnetwork.co.uk

• VAT on Cancer Drugs

Pain Killers

General Pain Killers

After a nephrectomy most people are advised to steer clear of certain pain killer drugs for fear of putting too much pressure on the remaining kidney. However, like everything, moderation is the key.

A recent article confirms a study done on the effects of pain killers on the kidney To see the article Click Here

Bellow are a few pointers picked up from other patients after they've spoken to their respective oncologists or specialists.

Always check with your own Specialist, Oncologist or GP before taking any medication

Also note that the trade names of drugs can vary from country to country

• "Since stopping taking some OTC medications one patient noticed that the bleeding stopped, and it seemed to have had a marked improvement in pain and general feeling and energy levels all around. The patient suspected that maybe the OTC medications were having an anti-clotting effect, mildly impeding the healing process, thereby prolonging the general pain."

• Another patient was "cleared to take motrin/advil in moderation"

• "OTC pain meds are much weaker than prescription medications (220mg vs 400) and are safe to take"

• "Tylenol is filtered through the liver and the amount that is allowed and safe to take for pain per day is 4 grams"

• "5/5 Methadone liquid. It was recommended by a local hospice MD as a cheap, effective pain killer."

• "Acetametaphin (Tylenol) metabolizes in the liver, as opposed to the kidney. That is why doctors recommend only to use acetametaphin, to protect against stress on the kidneys"

References

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Disclaimer

E&OE - Errors & Omissions Excepted